Charged Multivesicular Body Protein 2B (CHMP2B) forms part of one of the endosomal sorting complexes required for transport (ESCRT), specifically ESCRT-III. (ESCRT)-III proteins catalyse a number of membrane remodeling processes essential for many cellular functions with CHMP2B mediating the endosomal sorting of ubiquitinated transmembrane proteins into the multivesicular bodies (MVBs) for transport to lysosomes.
ESCRT-III comprises IST1, two isoforms of CHMP1, two isoforms of CHMP2, CHMP3, three isoforms of CHMP4, CHMP5, CHMP6 and CHMP7. The ESCRT-III proteins are expressed ubiquitously with CHMP2B having a specialised role in neurons during the formation and maintenance of synapses. Mutations in the CHMP2B gene results in two C-terminally truncated variants of the protein leading to an autosomal dominant form of frontotemporal dementia (FTD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, VPS2 Homolog B, Vacuolar Protein Sorting-Associated Protein 2-2,Charged Multivesicular Body Protein 2b
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
24kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm Late endosome membrane Peripheral membrane protein cytosol
Charged Multivesicular Body Protein 2B (CHMP2B) forms part of one of the endosomal sorting complexes required for transport (ESCRT), specifically ESCRT-III. (ESCRT)-III proteins catalyse a number of membrane remodeling processes essential for many cellular functions with CHMP2B mediating the endosomal sorting of ubiquitinated transmembrane proteins into the multivesicular bodies (MVBs) for transport to lysosomes.
ESCRT-III comprises IST1, two isoforms of CHMP1, two isoforms of CHMP2, CHMP3, three isoforms of CHMP4, CHMP5, CHMP6 and CHMP7. The ESCRT-III proteins are expressed ubiquitously with CHMP2B having a specialised role in neurons during the formation and maintenance of synapses. Mutations in the CHMP2B gene results in two C-terminally truncated variants of the protein leading to an autosomal dominant form of frontotemporal dementia (FTD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, VPS2 Homolog B, Vacuolar Protein Sorting-Associated Protein 2-2,Charged Multivesicular Body Protein 2b
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
24kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm Late endosome membrane Peripheral membrane protein cytosol
CHMP2B Antibody detects endogenous levels of total CHMP2B.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UQN3
Gene:
CHMP2B
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
CHMP2B Antibody detects endogenous levels of total CHMP2B.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UQN3
Gene:
CHMP2B
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Cookies:
X
We use cookies to help personalise and improve your web experience.
By using our website you consent to our use of cookies, some of which may have already been set on your device.
View our Cookie Policy to learn more.
