Charged Multivesicular Body Protein 2B (CHMP2B) forms part of one of the endosomal sorting complexes required for transport (ESCRT), specifically ESCRT-III. (ESCRT)-III proteins catalyse a number of membrane remodeling processes essential for many cellular functions with CHMP2B mediating the endosomal sorting of ubiquitinated transmembrane proteins into the multivesicular bodies (MVBs) for transport to lysosomes.
ESCRT-III comprises IST1, two isoforms of CHMP1, two isoforms of CHMP2, CHMP3, three isoforms of CHMP4, CHMP5, CHMP6 and CHMP7. The ESCRT-III proteins are expressed ubiquitously with CHMP2B having a specialised role in neurons during the formation and maintenance of synapses. Mutations in the CHMP2B gene results in two C-terminally truncated variants of the protein leading to an autosomal dominant form of frontotemporal dementia (FTD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, VPS2 Homolog B, Vacuolar Protein Sorting-Associated Protein 2-2,Charged Multivesicular Body Protein 2b
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
24kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm Late endosome membrane Peripheral membrane protein cytosol
Charged Multivesicular Body Protein 2B (CHMP2B) forms part of one of the endosomal sorting complexes required for transport (ESCRT), specifically ESCRT-III. (ESCRT)-III proteins catalyse a number of membrane remodeling processes essential for many cellular functions with CHMP2B mediating the endosomal sorting of ubiquitinated transmembrane proteins into the multivesicular bodies (MVBs) for transport to lysosomes.
ESCRT-III comprises IST1, two isoforms of CHMP1, two isoforms of CHMP2, CHMP3, three isoforms of CHMP4, CHMP5, CHMP6 and CHMP7. The ESCRT-III proteins are expressed ubiquitously with CHMP2B having a specialised role in neurons during the formation and maintenance of synapses. Mutations in the CHMP2B gene results in two C-terminally truncated variants of the protein leading to an autosomal dominant form of frontotemporal dementia (FTD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Category:
Primary Antibodies
Other names:
ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, VPS2 Homolog B, Vacuolar Protein Sorting-Associated Protein 2-2,Charged Multivesicular Body Protein 2b
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
24kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm Late endosome membrane Peripheral membrane protein cytosol
CHMP2B Antibody detects endogenous levels of total CHMP2B.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UQN3
Gene:
CHMP2B
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
CHMP2B Antibody detects endogenous levels of total CHMP2B.
Blocking Peptide:
A corresponding control peptide is available for this antibody (please email tech@nktscientific.com for details)
Conjugate:
Unconjugated
Uniprot:
Q9UQN3
Gene:
CHMP2B
Format:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
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