Charged Multivesicular Body Protein 2B (CHMP2B) forms part of one of the endosomal sorting complexes required for transport (ESCRT), specifically ESCRT-III. (ESCRT)-III proteins catalyse a number of membrane remodeling processes essential for many cellular functions with CHMP2B mediating the endosomal sorting of ubiquitinated transmembrane proteins into the multivesicular bodies (MVBs) for transport to lysosomes.
ESCRT-III comprises IST1, two isoforms of CHMP1, two isoforms of CHMP2, CHMP3, three isoforms of CHMP4, CHMP5, CHMP6 and CHMP7. The ESCRT-III proteins are expressed ubiquitously with CHMP2B having a specialised role in neurons during the formation and maintenance of synapses. Mutations in the CHMP2B gene results in two C-terminally truncated variants of the protein leading to an autosomal dominant form of frontotemporal dementia (FTD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
100 µg in 100 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Antibody Number:
10090
Category:
Primary Antibodies
Other names:
ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, VPS2 Homolog B, Vacuolar Protein Sorting-Associated Protein 2-2,Charged Multivesicular Body Protein 2b
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
24kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm Late endosome membrane Peripheral membrane protein cytosol
Charged Multivesicular Body Protein 2B (CHMP2B) forms part of one of the endosomal sorting complexes required for transport (ESCRT), specifically ESCRT-III. (ESCRT)-III proteins catalyse a number of membrane remodeling processes essential for many cellular functions with CHMP2B mediating the endosomal sorting of ubiquitinated transmembrane proteins into the multivesicular bodies (MVBs) for transport to lysosomes.
ESCRT-III comprises IST1, two isoforms of CHMP1, two isoforms of CHMP2, CHMP3, three isoforms of CHMP4, CHMP5, CHMP6 and CHMP7. The ESCRT-III proteins are expressed ubiquitously with CHMP2B having a specialised role in neurons during the formation and maintenance of synapses. Mutations in the CHMP2B gene results in two C-terminally truncated variants of the protein leading to an autosomal dominant form of frontotemporal dementia (FTD).
Product Type:
NS Reagents Antibody
Antibody Type:
Polyclonal
Format:
50 µg in 50 µl PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
If you would like us to check if this antibody is likely to bind to this protein from a different species please contact us. We are happy to check for you.
If you would like further information regarding the immunogen used in the production of this antibody or have a query about whether this antibody will bind to your protein/species please contact us and we can do the analysis for you.
Antibody Isotype:
IgG
Application Details:
WB 1:500-2000. IHC 1:50-200.
Antibody Number:
10090
Category:
Primary Antibodies
Other names:
ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, VPS2 Homolog B, Vacuolar Protein Sorting-Associated Protein 2-2,Charged Multivesicular Body Protein 2b
Research Areas:
Neuroscience
NS Reagents Product Area:
Neuroscience
Molecular Weight:
24kDa (Intended as a general guide and does not allow for all isoforms and species variations)
Subcellular location:
Cytoplasm Late endosome membrane Peripheral membrane protein cytosol
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
CHMP2B Antibody detects endogenous levels of CHMP2B.
Immunogen:
A synthesized peptide derived from human CHMP2B.
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
CHMP2B Antibody detects endogenous levels of CHMP2B.
Immunogen:
A synthesized peptide derived from human CHMP2B.
Cross Reactivity:
Human,Mouse,Rat
Conjugate:
Unconjugated
purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Concentration:
1mg/ml
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Gene ID:
25978
Gene:
CHMP2B
Swiss-Prot:
Q9UQN3
Molecular Weight:
32 kDa
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